Ceftriaxone does not reach the brain

Under normal circumstances, Ceftriaxone (brand name Rocephin) does not enter the central nervous system and therefore is useless against ALS or Lyme disease, especially in the doses typically used.

Trials to treat ALS with Ceftriaxone are therefore doomed to fail, because Ceftriaxone does not pass the blood-brain barrier and thus does not reach a sufficient concentration in the central nervous system. The Chinese know this, why don't we? None of the antibiotics in the class of Cephalosporins enter the brain. Therefore, all these antibiotics are useless without using a method to let them pass the blood-brain barrier.

We can adopt a conspiratorial approach and say this was deliberate, but a simpler explanation exists: The problem with most medical specialists is that they are not scientists like engineers or mathematicians. They are more comparable with bureaucrats or lawyers. They learn some facts, blindly accept them but do not understand the reasons behind them. Doctors think that because Ceftriaxone cures brain infections such as Meningitis, that it passes the blood-brain barrier. However, they do not understand that Ceftriaxone only passes the bbb because the capillary vessels are inflamed. Without such inflammation, there is no bbb penetration, since Ceftriaxone's molecule is not lipid-soluble and < 500 Daltons.

Lyme neuroborreliosis often does not result in Meningitis. Meningitis is the inflamation of the capillary bloodvessels that form the blood-brain barrier. Meningitis degrades the structural integrity of these vessels, and an increased penetrability for larger molecules is the result. There often only occurs Lyme Meningitis in the acute untreated stage and as soon as antibiotics reach that area, the Meningitis subsides and Cef will not penetrate anymore, leaving the remaining bacteria unexposed. Bb s.l. is microaerophillic so it moves out of the Oxygen-rich parenchyma and nestles deeper in the brain, such as inside neurons. It has a great tropism for Myelin as well.

The below study shows that Ceftriaxone does not penetrate the bbb, except in the presence of Meningitis:

Zhonghua Nei Ke Za Zhi. 1989 Jun;28(6):340-2, 381.
[The penetration of cephalosporins across the blood-brain barrier and its clinical significance].
[Article in Chinese]
Zhang YY, Wu PJ, Zhang Q.

ceftriaxone"The penetration of Cefuroxime (CXM), Ceftazidime (CTZ), Cefotaxime (CTX), Ceftizoxime (CZX), and Ceftriaxone (CTRX) across the blood-brain barrier was studied in 119 patients with or without meningitis after an intravenous injection of 2 grams. Cephalosporins were undetectable or their concentrations very low in the cerebrospinal fluid (CSF), when there was no inflammation in the meninges. On the contrary, the mean CSF concentrations of cephalosporins were 2.21-5.36 micrograms/ml and the CSF/serum ratios 3.73-31.80% in acute stage of purulent meningitis."


Copyright violations result in a DMCA to the host + invoice with our content licensing fee.

1.  Bruce Eckerd    Friday, May 9, 2014

So, what antibiotics penetrate the blood-brain barrier?

2.  Sarah Vaughter    Friday, May 9, 2014

The only orals I know of and have positive experience with is Doxycycline and Minocycline.

However, when encephalitis is present (it often is, with infections or inflammations of the brain), larger molecules also penetrate the BBB and Amoxicillin (4 or 6 grams/day) could help greatly, until the encephalitis is gone.

I am not a doctor and this is not medical advice. Following my recommendations (which are unqualified opinions) could result in death.

3.  Amos Echevarria    Sunday, August 24, 2014

Minocycline is very efficient at crossing the BBB. The side effects though are dizziness and extreme light sensitivities; the main reasons I stopped taking it. Doxycycline is a lot easier to handle. Lots of nausea, but can be countered by taking it 30-60 minutes after food. I must admit, I have had very favorable results from Doxycycline. It works very good.

4.  sarah    Thursday, October 16, 2014

I had severe brain infflamation that was only helped by the Bicillin Injection -which DOES penetrate the blood brain barrier. Ask your doctor for it. Orals did nothing for me

5.  GMD    Wednesday, June 24, 2015

I would like to try doxycycline and minocycline. I have an evil oral infection, seems to be in gums, and jawbones. I lost all my teeth. The minocycline seemed to help the infection when I had my teeth, however, it always made my teeth yellow. I wonder why?

6.  Sarah Vaughter    Wednesday, June 24, 2015

I got terrible black pigment spots near the gumlines from it, which could be removed by the dental hygenist. It seems to have something to do with the ability of the antibiotic to bind with Calcium compounds to form dark substances or something.

When responding to another comment, please mention its number.
Comments need to be approved. Check updates to this page with F5.
We reject comments with profanity, sloppy writing, suspected SPAM,
requests for medical treatment advice, customer support issues or
criticism to the article without using logical, scientific arguments.


After Saturday comes?